Originally Posted by Fancychooklady
I'm sorry I went through the links and found them to be lacking in detail. What do earth worms have to do with chickens ?
Those were for Kathy; my link from the previous post didn't work
It was about albendazole, wormer.
I tried to cut a paste from another post; the general information, to save sifting and trying to read all that technical jargon... I hope it works lol, I get frustrated at little phone research ha-ha
International Journal of Research in Ayurveda & Pharmacy;Jul/Aug2013, Vol. 4 Issue 4, p530
The crude extract of Carica papaya (papaya) seeds (CP) and Cucurbita maxima (Pumpkin) seeds (CM) were assayed against adult earthworms (Pheretima posthuma) for the evaluation of anthelmintic activity. Various concentrations of both extracts were tested and results were expressed in terms of time for paralysis (P) and time for death (D) of worms. Albendazole was used as a reference standard. The result showed that in both of the extracts (i.e. CP and CM) dose of 60 mg / ml possesses more wormicidal activity. The time of paralysis was 1.88 Â± 0.52 minute and 1.93 Â± 0.57 minute whereas the time of death was 3.45 Â± 0.17 minute and 4.90 Â± 0.18 minute in the case of Carica papaya and Cucurbita maxima respectively. In conclusion, the use of seeds of Carica papaya (CP) and Cucurbita maxima (CM) for anthelmintic activity have been confirmed and further studies are suggested to isolate the active principles responsible for the activity. Both the extracts showed significant anthelmintic activity, but the comparative study showed that out of these two, Carica papaya proves to be a better anthelmintic remedy.
The pumpkin Cucurbita moschata is an annual dicotyledonous vegetable, belonging to the Cucurbitaceae family. It is used as a medicinal plant for prostate and bladder problems, and as an anthelmintic, galactogogue, and anti-emetic. Pumpkin seed is used as a vermifuge in several countries, and C. moschata seed contains a wide range of bioactive compounds, some of which could possess anthelmintic properties, prompting experimental studies. This chapter reviews the experimental data on the anthelmintic evaluation of C. moschata seed.
This chapter outlines the pharmacological actions and potential uses of pumpkin and its extracts. Pumpkin seed oil contains 9.5-13% palmitic, 6-7.93% stearic, 0.04% arachidic, 37-39% oleic, and 44% linoleic acid. The seed also contains a wide range of bioactive compounds. The aqueous extract of the seeds of C. moschata showed efficacy as an anthelmintic in humans. The use of aqueous extracts of pumpkin seeds in the treatment of puppies experimentally infected with heterophyasis gave promising results, with even better results when combining extracts of areca nut and pumpkin seeds than when giving either extract alone. The secondary metabolites suspected to be responsible for anthelmintic activity in C. moschata seed are a triterpenic compound named cucurbitacin B, a non-proteic amino acid named cucurbitin, saponins, and sterols. The non-proteic amino acid cucurbitin, which is only present in the seeds, has been focused on as the active principle responsible for anthelmintic, notably taenicidal and schistosomicidal, activity. Cucurbitin is also used as an anti-allergen for the preparation of cosmetics and pharmaceuticals, particularly dermatological, products. Despite the focus on cucurbitin as the active principle, other secondary metabolites present in the seeds of C. moschata might also be considered as anthelmintics. The non-proteic amino acid cucurbitin (3-amino-pyrrolidine-3-carboxylic acid) is suspected to be the active principle. Cucurbitin was mostly reported to have no side effects, and only a weak level of toxicity was described in dogs and humans.
From the study, it is observed that Z. zerumbet has shown better activity than C. maxima at a higher concentration (100 mg/ml) compared to standard Albendazole (100 mg/ml). The comparison of death time for both the plants in different concentrations with respect to standard (Albendazole).