If chicks have what I like to call a "panic room", where only they can fit the entrances (and there should be more than one), it not only provides optimal safety, but it helps develop self confidence in the chicks so they're better adjusted going forward.
Food and water is inside this panic room so the chicks don't have to be stressed and fearful trying to compete for essentials. It's a place for them to relax and be themselves without having to be on guard all the time.
Almost eight years ago, when I was introducing my first three baby chicks to my two adult hens, I quickly came to the conclusion I needed some sort of safe pen for the babies if only to keep the adult hens from taking over the chicks' food. I tacked up a small enclosure in one corner of the run, and made a small opening into it that the hens couldn't fit through. By that time one hen had developed a real fondness for the chick food and I found her stuck in the opening leisurely finishing off the chick starter. So I tore the pen down and built a larger enclosure so I could get the food farther away from the openings.
Later on, I built a new run and incorporated a chick pen or panic room into it as a permanent feature. Then I created small chick portals in every partition in the run where a chick might get trapped against a wall or stuck in a corner with no escape. This provides safety for baby chicks so they can have free access to the entire run and still have a safe place that they can use until they're around three months old. Currently, I'm using the panic room for a two-year old abandoned hen I just adopted, so it's anything but wasted space.
Everyone who utilizes a panic room for their chicks have had peace of mind and no casualties. I highly recommend it.