In a top bar hive the bees will almost always locate the brood nest nearest the entrance holes and the honey stores behind that. If the hive has entrance holes in the centre then if they are allowed to expand both ways they will often store honey at both ends. If you live in an area where winters are cold and long, it is helpful to move all the honey stores to one end so that the bees only move in one direction. during the winter. Personally I prefer end entrances and then there is no need to rearrange anything.
I would never move the location of the brood nest as the bees have chosen where to have it for a reason.,,, usually near to the entrance so that pollen can be easily unpacked and stored around the brood nest to feed the brood. The further the bees have to walk through the hive, rubbing shoulders with other bees as they do so, the more chance that their pollen sacs will be dislodged and drop to the bottom of the hive.