There are some pesticides that can kill several times down through the food chain but these pesticides are mostly of the ORGANIC or natural variety. One that comes readily to mind is the ORGANIC pesticide 1080 that in the past has been used for warfare purposes and another is the ORGANIC pesticides Saponin, Ronote, and Pyrethrin which is deadly to aquatic life but harmless to most higher organisms. Then there is Strychnine which will kill you deader than 4 O'clock but which chickens and other birds love more than a stoner likes pot. I don't know if it still is but at one time Strychnine was available to the pet bird trade to make canaries in pet stores forget about their troubles and sing like a drunken sailor. Also in that ORGANIC camp of deadly chemicals do not forget about Opium and it's many derivatives. I suspect that Strychnine is still given to chickens at poultry shows to impress the judges with a chickens' liveliness.
When designing purpose made pesticides it is relatively easy to customise the effect of the pesticide on its intended target.
When designing purpose made pesticides it is relatively easy to customise the effect of the pesticide on its intended target.