Backstory: Four weeks after their arrival, one of my 'started' Dominique pullets (at age 16 weeks) developed the foamy discharge in the corner of her right eye. No nasal discharge, no odor. A bit of redness in her facial area, too. She was/has been acting fine, perky, curious, eating, drinking as normal. Entire flock was put on oxytetracyline in all water sources for two weeks. No improvement in this pullet, but no other flock members (age 1 to 4 1/2) showed signs of problems. Same Dom pullet was then given a 5 day course of Baytril injectible per veterinarian consultation. No improvement on Baytril, either. She continues to have the eye foam, slightly reddened face, (no nasal discharge, no odor) but is running around, eating, drinking, exploring. No breathing problems to date. Yesterday, her sister, another 'started' Dom pullet (now age 19 weeks) showed first signs of eye foam, also in her right eye. Slight reddening of face, no odor, no nasal discharge, no breathing problems, otherwise acting fine in her behavior. I'll attempt to get a swab or fecal sample (whichever is needed) tested tomorrow, thinking that this is MG, but wondering if I need to resort to sulfa drugs in the water at this point. I'm saddened that my first Dom did not respond to Baytril. These are pure pets having no contact with other chicken owner/breeders. I'm hoping they can be saved and that they'll recover, at least symptomatically, understanding that I likely have a compromised flock. Has anyone needed to resort to multiple medications in order to get on top of such a disease process? Experienced input is appreciated. ******************** UPDATE Well, since Baytril did not resolve symptoms, I went to Denegard (oral, mixed in water) for 5 days. Also used it in making feed "mash". No change. The two symptomatic Doms, now about 20 weeks, are still showing signs of occasional eye "bubbles", although the 'sister' Dom's problem seems a bit less severe. Today, after vet consultation, I'm starting eye drops twice a day (neomycin/polymyxin B/dex) and hoping against hope that I'll see some results. Note that I do not have a definitive diagnosis from blood or fecals yet (life has been getting in the way). Both girls are active, eating, drinking, running around, funny, and enjoying our mild weather. These girls need some positive vibes from the BYC crew, please!