It is definitely sad to see a dog I've had for nearly thirteen amazing years start going downhill (he is turnnig 15 in January, we adopted him shortly after his 2nd birthday from a fellow military family). For the past couple of years he has been kinda stiff, but was able to do well. He'd get a low dose aspirin to help with his discomfort (65lb dog, btw). But recently he started doing worse (signs of pain), so off to the vet he went. The plan is for him to be on tramadol for two weeks to get the aspirin out of his system, then put him on rimadyl. Tramadol is an opiate pain reliever, and it makes him a bit zonked, but comfortable. I've become concerned about the rimadyl, though. That it can cause acute liver damage pretty quickly, even given in proper doses. Noah's liver and kidney function is fantastic (got the blood test results yesterday), and is very healthy otherwise, so I'd hate it if the rimadyl caused his liver to fail. Are my worried unfounded, you think? I am searching for scientific studies on the matter, of course, rather than hearsay. Do you know of any good places to find sound information on dogs and rimadyl? I plan to discuss my concerns when I see the vet next. All I want is for him to be comfortable. He knows he can't tackle stairs (the house is based around one level though, so he never has to leave the main floor anyway), and for a long time, carpets have been laid down over slick hardwood to make walking easier for him, and favorite sleeping spots are lower. He seems very happy and content, still having the occasional burst of energy and play (deaf as a post so recalling him is hard, haha), and little signs of pain since the tramadol. But I am not sure if the vet wants to keep him on an opiate, even a low dose, indefinitely.