Turns out my cats WILL take a large pill, broken into 1/4s, if you just wrap each piece in a glob of cream cheese. We tried for an hour to get KiKi and Kitty to each take a large pill. DH got bit and scratched. I got bit and scratched. DH finally gave up and started loading a shotgun I persevered and decided to try the cream cheese. Piece of cake...just for future reference.