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Nope would never buy from a pet store. Those are uaually puppy mills with little thought about the dogs that are bred. I would stick with good breeders with a solid reputation for their dogs. The 25% purebred dogs in the shelter may be a gamble with your children at risk because you...
25% of all dogs in shelters are purebred.
And if your "purebred" dog comes from a petstore, then it comes from a puppy mill. You still wont' know what you are getting.