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They aren't likely to be inbred or closely related to each other. You may have just had one sickly chick, and that can be caused by man factors.

I think OEGB, since the earlobes are red and not white. She has interesting coloring with the little black spots (unless that is just the photo.) Two siblings can hatch healthy chicks, but there is a bigger chance of problems, especially if the siblings are inbred themselves.