For the harsh chemicals you buy, you should read the side effects and instructions. Often the chemicals kill the surrounding tissues and have to be washed off before they do that, or they're not effective and have to be attempted several times.
For honey, it's safe to leave on. I didn't worry about flushing out my hen's eye because she didn't seem bothered. You can pour drinking water over it after 5 minutes or so, that goes well too. It's too gentle on macro organisms to worry about irritation and it won't kill cells. The Glucose Octase enzymes in honey which produce the hydrogen peroxide which nukes all bacteria regulates their output, keeping the levels perfect for killing microorganisms ( bugs ) but not macroorganisms ( chooks / people ).
You can reapply honey whenever, but once day is more than enough to nuke new bugs. The body would be able to deal with what is left after a single nuking.
There are thousands or millions of articles and news reports about it. https://www.google.com.au/search?q=honey+++antibiotic-resistant&tbm=nws&tbs=ar:1
forget Manuka, regular honey is best. Manuka is just honey with extra advertising.
Edited by GodofPecking - 1/22/16 at 4:12pm