YES. Especially the big, fast ones!!
In the barn, I have the kind that laugh at you when you try to smash 'em. Those get a good shot of fly spay (horse variety). Not a pleasant way to go for them but very effective ;-)
Hair spray is my go-to for the indoor ones. Slows them down so you don't miss them and they can't run under something and lurk.
Can you tell I hate spiders lol.
Here's another one- should a cornered snake be able to end their life in a mousetrap??
This one was in my barn a few months ago:
Unfortunately, it was still alive so I had to go find my husband's hatchet and dispatch of it while my children looked on 😳
Fortunately, I am not scared of snakes :-)