The Horned Toad (aka Horny Toad Lizard) is the only one I know of that squirts blood from its eyes, though it's rare for it to do so. We've handled many of them from baby to full-grown elder and have yet to be squirted.
http://www.asknature.org/strategy/32df43605fa6de230f3c3b4fd2b49f80 This article has a good description of this defensive mechanism used by horned lizards. It seems they use this as a last defense and handling them gently probably does not inspire in them a need to do this. I've also handled them and never seen one do this.
Yeah, I've had one or two squirt, but they have to be pretty alarmed to do it. I leave them alone, as they eat more ants than any other critter I've seen. I used to watch one out in my driveway, it would sit about a foot away from an anthill, and for hours on end, it would patiently gobble every ant that came out to play.
Last edited: