I just turned 46 and have been told I'm in the transition from peri-menopause to full-blown menopause. I took progesterone cream for a year and then this year starting in January I started on Prempro. I wanted to take HR. I have had such a mild menopause. Other than loss of periods (which are back somewhat due to HR) I haven't had anxieties or heart palpitations or many of the other awful symptoms I've heard about. I had very mild hot flashes at night that have also gone away. It took me two years to even realize I was in peri. I was a member of a menopause message board, but everyone was so negative that I finally stopped going there~ imagine that!