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She could be a bit cold, at 3 weeks they should be around 70-75 degrees. How feathered out are they? You could try adding a lower watt heat lamp, to see if she perks up a bit, or up the temperature of the room to see if she improves, if she doesn't than you know it's not that. Have you always...

How often do you clean the box. Is there wet spots? There should always be good ventilation and exchange of air. Brooding inside can cause stale air and potentially things like brooder pneumonia. Do you keep a window open? What is the room temperature?

That's a sign it's not feeling well, without other symptoms it can be hard to pinpoint the problem. It could be anything from cocidiosis to abnormally formed organs, and anything in between.