Hmmmm....that is strange!
From what I know, a drake cannot quack - the vocal structure is different between the sexes, making it physically impossible.
Your girl probably just has some hormones out-of-whack. Either that, or she's a hermaphrodite!
Sometimes a duck will go through a "sex change" (something like menopause I guess), where she stops laying and develops male plumage (due to a hormonal change when egg production stops). Her voice would still be the same, but she'd look like a drake and wouldn't lay any eggs.
There's an example...