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I can't speak for others, just my own experience. Opening the foot creates a large gateway for bacteria to enter the bloodstream. It also risks cutting too deeply and adding another injury to the foot. It takes more time and materials and follow up care. Confining a duck is no fun for...

I think the duck would do well to see a vet, if you can swing it. Sounds like the infection is systemic, so she will need some serious care (this is my gut feeling). Cutting is not a good first resort, because it opens the foot up to worse infection. If there is not just one obvious place...

Stamper, I agree, with the entire foot a bit swollen, and her underweight, I would probably go with more than just the topical antibiotics. You say you have some on hand, while it is your decision, my gut is that I would begin a round of antibiotics for her. I lost a duck to egg yolk...

What I do when I first spot it is give the foot a good cleaning just so that I can really look at it. From the photo, looks like the toe on the left (which would be on her right, right?) seems to have a bit of infection in it as well. With bumblefoot, there isn't pus as I usually think of it...

That looks like bumblefoot to me. She needs to start getting antibiotic ointment a couple of times a day until it clears up. Looks like you may have found it early enough not to need surgery, which would then require her to be confined a little bit until the foot sealed up again. Do you have...