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I didn't give my dogs anywhere near that type of dosage and they have had issues and demonstrated toxic reactions - the same that were listed and not even at that high of dose. In fact one of my current dogs cannot have any chemical flea and tick "preventative" whether it is topical or internal...

This: Signs of Toxicity - Animals Dermal exposures to cats and dogs may cause temporary paresthesia and neurological signs as evidenced by paw flicking or ear, tail or skin twitching, or rolling on the ground.5 Cats exposed dermally to some permethrin products may experience hyperexcitability...