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DE is quite controversial. One clear fact is that it is very irritating to the respiratory tract. It is strongly recommended that you wear a mask when handling it, but then you won't have any masks for your chickens. People have had their birds become ill, even die from depending on DE to...

https://www.backyardchickens.com/t/818674/are-these-some-kind-of-egg-clusters/0_20#post_11897957 http://ohioline.osu.edu/vme-fact/0018.html