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I think it's because it can go inactive. -Kathy

So to answer your original question, yes, you need to make a fresh batch each day. Additionally, if you have some that aren't drinking enough you need to figure out how to get more into them. Many people will make a mash using crumbles and medicated water. -Kathy

If you think you have coccidiosis and are going to treat it, I strongly suggest that you buy something that will allow you to make a fresh batch each day. That's the obvious thing to do, right? -Kathy

No, but if I did and it proved too difficult to make fresh daily I would buy some waterers. -Kathy

I change mine daily. If you're worried about waste, just make less. -Kathy

Some people use give the .006% dose for one to two weeks after treatment. FDA recommendations: http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=013-149 "Chickens Indications: For the treatment of coccidiosis. Amount: Administer at the 0.012 percent level in drinking water...

It does sound like too much... the amount of amprolium per liter needed is 254mg, which is: 20% powder is about 1/2 teaspoon 9.6% liquid is 2.65ml. -Kathy