I have 25 birds in a 8'X8'X7' high coop with attached 8'X24'X9' high run. I clean the coop thoroughly every week which includes changing the bedding, removing and scraping/hosing down the roosts and ladders, sweeping the run, and applying DE to the new bedding. Like Southern Ann I change the water twice a day (in the AM before work and after I get home), and make sure to clean any debris out of their feed troughs. To me cleanliness is next to Godliness, and the gals seem to appreciate it quite a bit. So far I haven't had any problems with lice or anything but I've only been chickenin' since January so it's a little early to tell whether this schedule will work over the long haul. Hopefully it will.