ISA Browns are a commercial egg-laying hybrid, specially bred to produce a lot of relatively large eggs. If you check they are typically fed a ration of about 16% protein. No treats or anything else, just that ration. Since they are so attuned to egg production if you feed them more protein they are more likely to have egg related medical issues. Things like prolapse, internal laying or releasing additional yolks that can lead to double yolkers, multiple eggs in a day, soft or thin shells, all kinds of problems. There is a reason the professionals feed those hybrids a 16% ration. Profit is better if the hens are not having medical issues.
How much room do you have? I understand they are two years old so it's been a while, but sometimes tight spaces make behavioral problems worse. It sounds like this being this bad is fairly recent.
Is it all of your ISA Browns or just one ringleader? Sometimes if you isolate a chicken for several days to a week you can knock them down in the pecking order and they change their behaviors.
I've not had your exact situation but occasionally one chicken will develop a dislike toward another. Or a flock will attack a specific chicken as OldHensLikesDogs said. You may be in the situation where you need to rehome one.