Updated - Corid and Amprol (amprolium) Dosing

[casportpony]

Or you can make a wet mash with the medicated water.

That works too.

 

[NewFlockOnTheBlock]

My chickens sometimes go for mash and sometimes they turn up their nose at it and only peck at it at best, so it's a bit unreliable. They will always go for a piece of bread though as it is a rare treat (unlike mash, which they get almost daily).

 

[MichelleKing]

Treating Coccidiosis with Corid, Amprol, AmproMed - The Correct Amprolium Dose


When treating coccidisosis in my own birds I use the severe outbreak dose (0.024%) for 5 days, then the 0.006% amount for 7-14 days.

Liquid dose:
2 teaspoons per gallon for five days, then 1/2 teaspoon for 7-14 days.

Powder dose:
1.5 teaspoons per gallon for five days, then 1/3 teaspoon for 7-14 days.

Math and references below:


The FDA, FARAD, and the mfg's say this:

Source: http://www.farad.org/vetgram/ProductInfo.asp?byNada=033-165

Give amprolium at the 0.012% level as soon as coccidiosis is diagnosed and continue for three to five days. (In severe outbreaks, give amprolium at the 0.024% level.) Continue with 0.006% amprolium medicated water for an additional 1 to 2 weeks. No other source of drinking water should be available to the birds during this time. Make fresh daily.

So what does that mean?

20% Powder
0.024% = no less than 1.5 teaspoons per gallon
0.012% = no less than 3/4 teaspoons per gallon
0.006% = no less than 1/3 teaspoon per gallon

9.6% Liquid
0.024% = no less than 2 teaspoons per gallon
0.012% = no less than 1 teaspoons per gallon
0.006% = no less than 1/2 teaspoon per gallon







Due to some confusion on dose amounts regarding the powder, I decided to do some research and this is what I have so far. For those of you that use powder Corid, if you have been using 1/2 teaspoon per gallon (~270mg) you haven't been using enough.

The preventative dose (.006%) for Corid Powder is 1/3 teaspoon.
The preventative dose (.006%) for Corid liquid is 1/2 teaspoon.

The moderate outbreak dose (.012%) for Corid Powder is 3/4 teaspoon.
The moderate outbreak dose (.012%) for Corid liquid is 1 teaspoon.

The severe outbreak dose (.024%) for Corid Powder is 1.5 teaspoons
The severe outbreak dose (.024%) for Corid liquid is 2 teaspoon.

Corid mixing instructions for preventative (.006%) and moderate (.012%) outbreak dosing.
http://www.corid.com/SiteCollectionDocuments/CORID Slim Jim-All.pdf

Amprol 20% powder:
http://www.asp-inc.com/products/documents/prodinfo/a/amp128.pdf

Amprol 9.6% liquid:
http://www.asp-inc.com/products/documents/prodinfo/a/amp96.pdf

FDA recommendations:
http://www.accessdata.fda.gov/scripts/animaldrugsatfda/details.cfm?dn=013-149
"Chickens
Indications: For the treatment of coccidiosis.
Amount: Administer at the 0.012 percent level in drinking water as soon as coccidiosis is diagnosed and continue for 3 to 5 days (in severe outbreaks, give amprolium at the 0.024 percent level); continue with 0.006 percent amprolium-medicated water for an additional 1 to 2 weeks."

And this link has these instructions:
http://www.drugs.com/vet/amprol-9-6-solution-can.html
"Poultry - as Soon As Caecal Coccidiosis Is Diagnosed, Give 0.024% Amprolium In The Drinking Water For 5 To 7 Days. Continue The Treatment With 0.006% Amprolium Medicated Water For An Additional One To Two Weeks. No Other Source Of Drinking Water Should Be Available To The Birds During This Time."

Here's the math, let me know if I made an error.

• There are 200mg of amprolium in every 1 gram of powder.
• 1 ounce = 3.5 tablespoons = 28.35 grams
• 200mg x 28.35 = 5670mg in 3.5 tablespoons of powder.
• There are 10.5 teaspoons in 3.5 tablespoons
• There are 21 1/2 teaspoons in 10.5 teaspoons
• 5670mg divided by 21 1/2 teaspoons = ~270mg per 1/2 teaspoon
• There are two 1/4 teaspoons per 1/2 teaspoon
• 270 mg divided by 2 = 135mg per 1/4 teaspoon

Amount of Amprolium (Corid or Amprol) powder per 1/4 teaspoon
​

• One 1/4 teaspoon = 135 mg
• 1/2 teaspoon = 270 mg
• 3/4 teaspoon =405 mg
• 1 teaspoon = 540 mg
• 1 & 1/4 teaspoons = 675 mg
• 1 & 1/2 teaspoons = 810 mg
• 1 & 3/4 teaspoons = 945 mg
• 2 teaspoons= 1080 mg

Amount of Amprolium (Corid or Amprol) liquid per 1/4 teaspoon
​

• One 1/4 teaspoon = 120 mg
• 1/2 teaspoon = 240 mg
• 3/4 teaspoons = 360 mg
• 1 teaspoon = 480 mg
• 1 & 1/4 teaspoons = 600 mg
• 1 & 1/2 teaspoons = 720 mg
• 1 & 3/4 teaspoons = 840
• 2 teaspoons = 960 mg

There are 4.92892ml/teaspoon, but the numbers above were calculated using 5ml/teaspoon

​

Here is what's in 1-10ml of the liquid

• 1ml = 96mg
• 2ml = 192mg
• 3ml = 288mg
• 4ml = 384mg
• 5ml = 480mg
• 6ml = 576mg
• 7ml = 672mg
• 8ml = 768mg
• 9ml = 864mg
• 10ml = 960mg

Bottom line, 1 teaspoon (540mg) of powder is equal to 5.625ml of liquid and 1/2 teaspoon powder (270mg) is equal to 2.8125ml liquid.

1/2 teaspoon of 20% powder = 2.8125ml of 9.6% liquid - Both have 270mg of amprolium.
3/4 teaspoon of 20% powder = 4.21875ml of 9.6% liquid - Both have 405mg of amprolium.
1 teaspoon of 20% powder = 5.625ml of 9.6% liquid - Both have 540mg of amprolium.
1.5 teaspoons of 20% powder =8.4375ml of 9.6% liquid - Both have 810mg of amprolium.
1.75 teaspoons of 20% powder = 9.84375ml of 9.6% liquid - Both have 945mg of amprolium.
2 teaspoons of 20% powder = 11.25ml of 9.6% liquid - Both have 1080mg of amprolium.



And if that doesn't convince people, here is another way I did it:

From:
http://www.asp-inc.com/products/documents/prodinfo/a/amp128.pdf:

Dosage Level Mixing Directions
0.024% Dissolve 8 ounces of AMPROL 128 20% Soluble Powder in about five gallons of water in a 50-gallon medication barrel. Stir, then add water to the 50 gallon mark. Stir thoroughly.
0.012% Follow same directions as above but use 4 ounces of AMPROL 128 20% Soluble Powder.
0.006% Follow same directions as above but use 2 ounces of AMPROL 128 20% Soluble Powder.

Facts

• One pack = 10 oz. (283.5 grams)
• One ounce = 28.35 grams
• One ounce of powder = ~3.5 tablespoons
• 200mg amprolium per 1 gram

My twisted math for the .024% level
If 8 ounces (28.35g x 8 = 226.8 grams) are needed for 50 gallons, then 1/50 of that is needed for 1 gallon, right? So that would be 226.8 grams divided by 50 = 4.536 grams per gallon. (doing this as I type, so correct me if I'm wrong, please!)

So how much does a teaspoon of Corid or Amprol powder weigh? Anyone know? Well, time to break out my gram scale and do some weighing... also have a call into the mfg of Corid and I'm expecting a call back from them.

Just got a call back from them and it is 4.536 grams per gallon. He also said that it's a very safe product and the risk of overdosing is very slim.

-Kathy


Disclaimer:
In the past I have treated my chicken chicks with 2 teaspoons of the liquid for 5-7 days, that's it, but I *might* try the .006% follow up the next time I have to treat chicks.

This is so useful i cant even tell you. THANK YOU!!!!!!

 

[pedalmonkey]

H

Just wanted to bump this page in the middle so it may be seen somewhere besides the front.
I copy and pasted it in an e-mail draft so i could always know where it was just in case i even need the info.

Hello. I wasn't a member until very recently when a friend of mine referred me to this particular page and post concerning the use of Corid powder and liquid for coccidiosis, which I was desparate to find because I had a lame chicken. Unfortunately, she died (the chicken, not my friend) but I was at least able to learn more from it.
For mass percent dosing information, head to the good ol' FDA website. It's free and an example of good government information, just like PubChem, PubMed, NIST, etc.
Here's your link: https://www.fda.gov/AnimalVeterinar.../BlueBirdLabels/ucm081798.htm#Laying_Chickens

The dosing of Corid recommended by the FDA for a severe coccidiosis outbreak is .025%. The formula for determining mass percent is:
{(mass of solute) / (mass of solute + mass of diluent)} x 100.
Stick with SI measurements, folks. It's easier, more accurate, and less confusing. It's also the 21st century. Go metric. Rant over.

Don't have a metric mass balance, lab, or calibrated glassware for mixing? Don't worry about it.
Here's the quickest way to figure how much product to use (there is absolutely no shame in using a calculator):

Target solution is .025% mass percent.
Corid liquid stock solution is a 9.6% solution with 96mg/mL. That is to say that there is 96mg Amprolium in 1mL of stock solution. Multiplied by 1000, the stock solution is 96g/L, so we need to find the dilution factor.
9.6%/.025% = 384
384 is your dilution factor. Check by 9.6/384 = .025
If 96g/L is 9.6%, and the target solution is a 1L mixture at .025%, then
(96g/1L) / 384 = 0.25g/L. That is 250mg of Amprolium in 1L of water.

If there are 96mg/mL in the stock solution, and we need 250mg/L in our final solution, then (250mg/L) / (96mg/mL) = 2.604mL stock solution in 1L of final solution.

That's about ½t in 1L of final solution. "About" is fine for Amprolium because the risk of overdose is pretty low.
It's a good habit to put the stock solution in the calibrated mixing vessel before adding the diluent (water). The reasons we do this in the lab are for both safety and accurate measuring purposes, as the formula for measuring mass percent is:
{(mass of solute) / (mass of solute + mass of diluent)} x 100.

Happy mixing.

 

[casportpony]

Hello and welcome to BYC! Thanks for your post. Did you notice that the FDA page you're referring to is for medicated feeds, not medicated water?

For severe outbreaks, the FDA recommends 0.024% for water for 5 days, then 0.006% for 7-14 days.

 

[FluffTheDuck]

Hello and welcome to BYC! Thanks for your post. Did you notice that the FDA page you're referring to is for medicated feeds, not medicated water?

For severe outbreaks, the FDA recommends 0.024% for water for 5 days, then 0.006% for 7-14 days.

Just wanted to underline the "severe".

 

[pedalmonkey]

HOLY SHNIKIES!
My bad. Sorry. I should have copied the link from VETGRAM:
http://www.farad.org/vetgram/ProductInfo.asp?byNada=033-165
Upon further review...
The teqnique still still holds for figuring out the dilution rates, though. If you use .024 mass/mass percent for the target solution, the factor becomes 400 instead of 384, so...
.024% = mathmathmath, yaddayadda = 240mg/L
more yaddayadda = 2.5mL of 9.6m/m% stock sln in 1L of water = .024m/m%
And THAT is almost exactly 1/2t per litre.

It is important to note that this works because water at normal temperature and pressure weighs 1g per 1mL of volume. This is not to be confused with its mass.

 

[casportpony]

240 mg per liter
Or
908.4 mg per gallon

 

[karenharvell]

Just so I am clear I don't want to do something to hurt my babies. Is the dosage (3/4 tsp/gal) listed for grown birds AND chicks? My babies are about 4 weeks old. I bought the 20% 10 oz powder today.

 

[casportpony]

Just so I am clear I don't want to do something to hurt my babies. Is the dosage (3/4 tsp/gal) listed for grown birds AND chicks? My babies are about 4 weeks old. I bought the 20% 10 oz powder today.

Most people use the severe outbreak dose of 1.5 teaspoons per gallon.

Treatment	20% Powder	9.6% Liquid
For 3-5 days	1.5 teaspoons per gallon	2 teaspoons per gallon
then for 7-14 days	1/3 teaspoon per gallon	1/2 teaspoon per gallon