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I wouldn't consider them safe at all. What are the walls of your run made of? If your run is made of anything climbable (chainlink, wood, chicken wire, etc.) and not covered, predators like possums and coons can climb it just like climbing a ladder. Smaller critters (young possums and skunks) can come through chain link. Leaving the door open at night would also leave them vulnerable to owls and early-morning hawk attacks. Can you cut a window and fasten the small mesh (hardware mesh / wire) over the window with screws? (most recommend running long wood screws through a firring strip and the mesh, fastening it to the window framing securely).