If I have the choice I get the vaccine.
As for a backyard flock, I know people have RIRs, but I hear they can be flighty or aggressive. Just not a breed I'm attracted to.
I have FBCMs or French Black Copper Marans. They lay fairly well, but they don't keep up with the leghorns or RIRs. I did like my Buff Orps when I had them. I have Lavender now.
If you want a variety of colors in your eggs, the Marans lays a chocolate brown. Ameraucanas lay a pretty blue egg and if you cross the two you get Olive Eggers. I have one that was crossed with Welsummer (another one of my breeds) instead of Marans and she lays an olive egg with terricotta speckles. I have EEs (2) but both lay pink eggs, hoping to breed one or two that lay green. I just got Silver Penciled Rocks and they are very pretty birds.
There are so many choices. My last flock I had everything from Maranas to Polish. I couldn't decide what I wanted, so I just bought everything. LOL
OK I still keep adding breeds, but I continually buy better lines and have several colors of some of the breeds.
Eventually you'll start seeing something that catches your eye and you'll decover your breed or breeds. It finally comes down to personal choice. Most of my birds get carried around by my 5 year old grand daughter. My roos take care of their girls, but they are cream puffs with people. The more you interact with them the better chance of them respecting you and being mellow around people.
I hope you find just what you want. You can check out the members' websites, ask questions, look around and get involved on the breed threads and all of that will help you make a decission that suits you.
Whatever you decide, I know you're going to love keeping chickens.