I'll be honest: depending on the size of my upcoming hatch depends on how rigid I go with the "don't open" rule. If I have a LOT of eggs in there, I open as they hatch so they don't trample the eggs. The last big hatch I had, the chicks rolled the eggs around a lot, and many unhatched chicks never hatched. When I "egg topsied" them, I found a great deal had pipped into blood vessels. I attribute this to possibly being because the eggs were rolled around and the chicks got disoriented in the shells. Also, if I am having a big hatch, the smell gets nauseating if I leave the babies in there with all the "organic matter" left over from the egg. What I tend to do is have a cup of lukewarm water standing by and I dribble this on some paper towels I always leave over the wire in the incubator before I close it back up and I haven't had any problems with shrink wrapping. While it's open, all of 30 seconds or less, I remove chick and egg shell and then immediately close back up.