I'm not a fan of chicken wire because after a year or so it starts to rust. I actually use neither chicken wire or hardware cloth. I use the 2" by 3" green coated garden fencing for my run. My chicken area is out behind our fenced backyard with 5 acres of woods around it. We have foxes, raccoon's, possum's, hawks, weasels etc and I have never had an issue with anything coming and grabbing any chickens during the day. At night mine get locked up in the coop. So i wouldn't see you having an issue using chicken wire for your run if you lock them up at night. Most predators are nocturnal.