Right-handed people seldom notice which hand I use, but other lefties often do. Occasionally, someone who has known me for years will be surprised to find out that I'm a lefty; maybe I'm not as "gauche" as I feel! For the most part, the ways I've adapted are automatic - things like sitting at the left corner of a table so that I don't lock elbows with a righty - so even my nearest and dearest forget that there is anything different about the way I do things.
The thing I find most frustrating is the "ergonomic" way that some things get designed. Right-handed scissors with straight handles are a little trickier with the left hand, but the sculpted handles that are so comfortable for the right hand are downright painful for the left hand. A brand of dish soap had a bottle that was designed with a grip in the shape of the bottle - for the right hand (that bottle has since been redesigned). When I crochet something, I have to reverse the directions; not everything translates the same when you hold the hook in the other hand!
