The only reason I intend on running hardware cloth is snakes, for the most part, in respect to eggs and biddies.
In all honestly, I have several cats, as do the neighbors, along with a number of dogs around.
I can see the coop from the house, albeit a little ways away, but the chickens are good at alarming you.
As far as the bigger land predators, I think a bottom layer of stronger wire and buried fencing, rocks, or an apron would generally be suffice. The rest, in my mind, is for the hawks and snakes.
You just need to decide if you are trying to protect your chickens like you would your children or if you are trying to protect them like....a chicken. I assure you, if chickens couldn't survive without being protected like the Pope, they wouldn't have made it to the year 2010. Free range chickens are great example of how they can manage quite well.
What predators are you aware of in your area?
This is one of the biggest things to focus on, as many of us may have different needs when it comes to coop/run setups.