Marek's disease and humans

[Kiki]

Full article:
https://www.ncbi.nlm.nih.gov/pubmed/26094506

A piece of the above article:

"However, in terms of the potential to cross the species barrier, there are a few herpesviruses, including B virus disease (CeHV-1), Marek's disease virus (MDV), Equid herpesvirus-1 (EHV-1) or pseudorabies virus (PRV), which are potentially able to infect different hosts."


What are your thoughts on this?

 

[Kiki]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815145/

 

[Tesumph]

(Rephrasing this here)
I think it is theoretically possible, only based on the zoonotic nature of similar DNA viruses. But I cannot find a single case of a human actually being infected with Marek’s so I will confidently say no, it won’t happen.

I am finding out a lot about how dangerous the leaky Marek’s vaccine is though, and it’s role in creating “hot” strains in the USA.
https://www.pbs.org/newshour/science/tthis-chicken-vaccine-makes-virus-dangerous

 

[Kiki]

(Rephrasing this here)
I think it is theoretically possible, only based on the zoonotic nature of similar DNA viruses. But I cannot find a single case of a human actually being infected with Marek’s so I will confidently say no, it won’t happen.

I am finding out a lot about how dangerous the leaky Marek’s vaccine is though, and it’s role in creating “hot” strains in the USA.
https://www.pbs.org/newshour/science/tthis-chicken-vaccine-makes-virus-dangerous

https://www.ncbi.nlm.nih.gov/pubmed/12791859

 

[Kiki]

One more https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156508/
"In a recent report, Laurent et al. (7) described the detection of MDV DNA in 41 (20%) of 202 human serum samples. However, they did not find any difference in the prevalence of MDV DNA between a group of individuals constantly exposed to poultry and another group of office staff. Simultaneously, they detected MDV DNA from five serum samples from chickens with clinical signs of MD and provided the alignment of the MDV gD sequences from all 46 serum samples. That report prompted us to perform a new study on the question of the possible spread of MDV to humans, although, so far, it has generally been accepted that MDV is strongly cell associated. The aim of this study was to investigate if we can confirm the detection of MDV DNA in chickens and humans if we use plasma as the source for nucleic acid isolation."

 

[Kiki]

https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0404-3

 

[Kiki]

https://www.cdc.gov/niosh/nioshtic-2/20039017.html

 

[Kiki]

THIS IS AN EXTREMELY INTERESTING READ.



http://www.microbiologyresearch.org...est&checksum=E81BABD10CFA1791344DA8CE066E2893

 

[redranger209]

So it infects humans, but doesn’t affect them? Like blackhead with chickens? All of those .gov pages are confusing as heck.

 

[dotporter]

I'm deeply disturbed by this. Not because of the potential spread to humans. It bothers me that the current method of vaccination for chickens is more of a problem than a cure.
https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-016-0404-3

Although, I find it interesting that there is a disparity in information regarding whether marek's can be spread to humans already. Maybe I'm missing something? Confirmed studies relate that twenty percent of tested human plasma shows MDV DNA.
https://www.ncbi.nlm.nih.gov/pubmed/11125176

I had no idea that MDV was being investigated as a source for MS in humans. Cool.
https://www.ncbi.nlm.nih.gov/pubmed/12791859

"Our results conØict with those of a recent report
in which MDV DNA was not detected in leukocyte DNA from
patients suffering from multiple sclerosis (Hennig
et al
., 1998).
However, the previous study used the TaqMan Øuorogenic
system. Therefore, as the authors themselves suggested, their
negative results may be due to there being only a small number
of MDV genome copies in the blood of the patients, below the
detection limit of the TaqMan method (Hennig
et al., 1998)." http://www.microbiologyresearch.org...est&checksum=50EFBA131DB63228CD1EF024966AD05B

Ah, so that's what I was missing. One lab used a method that they admitted wasn't sensitive enough to detect infection. Ok, so.... marek's may already exist in humans? And they've studied if it's related to MS and cancer????

I'm going to stop reading now. Thank you for making sure that I don't sleep tonight.