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Not an Emergency...Marek's in the Flock

Sorry for the delay here folks. I thought I'd update on my rooster, in case this information ever helps anyone.
This rooster was vaccinated as a chick with the HVT vaccine, both at hatch and a second time at approximately 3 weeks old. He was not brought onto my property (where there is no doubt some lingering virus) until he was about 3 months old.

Timeline:
Jan 13th - Slight limp noticed. Suspected injury or maybe twisted blood feather in foot (he's a cochin).
Jan 17th- Severe limp; bird did not want to put any weight at all on the bad leg. Scheduled a vet appointment.
Jan 20th - Seen by vet, various x-rays taken and the bird's history was discussed. Due to history and lack of other signs, we treated for a soft tissue injury with a 7-day course of Metacam (anti-inflammatory and painkiller).
Jan 28th - Went from limping to suddenly having no use of either leg to bear weight upon. Suspected Marek's at this point, and scheduled a vet appointment to run tests or even possibly put him down as I suspected he would degrade.
Jan 31st - Visited the vet. Various blood tests were run, and a PCR test was sent away for Marek's detection (though I can almost guarantee that it will be positive as even if he is not suffering from Marek's, he has likely been exposed). We were given more Metacam and a 10 day course of antibiotics (Trimethoprim/sulfamethoxazole) just in case he has an infection that is causing swelling and paralysis (see white blood cell count below). We were given this stronger antibiotic because he's a roo and we don't have to worry about him laying eggs.. and we are not going to eat him. This medication is NOT RECOMMENDED for use in animals to be used for food (including egg laying hens).
Today (Feb 10th) - No degradation in health; he continues to eat with vigor, his droppings are as healthy as any I've ever seen, his comb and wattles are a healthy color (and growing), he continues to gain weight as one would expect for a "teenage" rooster, he has started to crow, attempts to do all normal chicken activities such as preening, "dust bathing" in a towel, is chatty, alert, happy. He can raise himself up onto his hocks (ankles) but can not straighten the ankle joints. If I didn't get him blood tested, I'd almost think that he didn't have Marek's. But, the blood test really suggest that he does. I will explain them below.

His health has remained unchanged since the day he demonstrated paralysis (Jan 28th). He has neither gotten better nor gotten worse. It will be two weeks tomorrow since he started demonstrating paralysis. I was expecting some degradation of health by now; be it a loss of appetite or digestive problems or signs of organ failure. So far none of these things have happened.

Steps I am taking:
- Continuing his medication, as might be obvious, for the full course.
- Continuing to feed him high quality feed (that has vitamin supplements in it). I have been adding additional supplements of water soluble vitamins in case they can help, such as B-12 complex. I am trying nutritional yeast as well, which works out because he loves to eat it. I'm offering small amounts of cold pressed coconut oil too, as it may or may not be helpful for neurological problems. It can't hurt at this point.
- Varying the surfaces he sits on, from soft towels on the flat floor, to the arm of a chair (he can still 'roost' and likes to sit this way, and can hold his balance) to putting him in a sling so that he can get off his legs. We gently work his legs, too, just in case it helps him. It does not seem to cause him any distress.

Here is a scan of his bloodwork, as taken on Jan 31st.



Explanations:

PCV - This stands for Packed Cell Volume, and normals for birds are 35%-55%, so this number is good.
TS - I forget what this stands for, forgive me, but this number is normal.
RBC - His polychromasia is listed as slight, which is normal.
WBC - This stands for White Blood Cells. This is where things get hairy. His Lymphocytes are high (the highest you'd expect to see in a normal, healthy bird is 50%). His blood contains Reactive Lymphocytes, which means that they are actively fighting a disease. A few reactive lymphs are normal in any blood smear but his were elevated and this means his body is responding to some sort of disease. He also has lymphoblasts (blast lymphs), which are a normal part of a bird's immune system, but normally are not found in quantity in the blood stream. Their presence in the blood are often seen with cancerous lymphomas.
Smudge Cells - Smudge cells are broken cells that are not distinct. Large numbers of them, such as indicated here (Severe) indicate that the cells have probably been damaged by cancer; this is really simplifying this but when combined with the other test results is suggestive again of lymphoma.
TWBC - Total White Blood Cell count-- this is a bad number. Normals for birds are generally 5,000 - 15,000. My rooster scored 51,852 ... very high. Something is very wrong in his body and his immune system is going nuts.
Blood Chemistry- His blood chemistry is good, and indicates nothing like anemia, obvious deficiencies, etc. The only number that is high is the CK count (forgive me as I do not know the normals for this). CK count is Creatine Phosphokinase and high numbers for this usually indicate muscle damage, which may be from him bumbling around due to paralysis, or perhaps he is having muscle damage to his legs; it is hard to know.
One of the other results was mentioned by the vet as being suggestive of possible nerve damage, though I regret that I've forgotten exactly what she said (it was all a lot to take in at the time, as I had some other things going on as well).

Again I do not know how helpful this would be to anyone else, but just in case it is, I wanted to share it. I am not a vet nor do I have anything other than the most basic knowledge of hematology, so if my interpretations or memory of any of this seems wrong to you please let me know. I'm just a lay person trying to figure this all out rationally.

I will let you all know of any changes. We really want to try and save this rooster as he's more like the family dog than 'just a chicken' but I am also being realistic in knowing that if he has the Marek's Lymphomas, his time is limited with us....

Further reading on hematology in avians in case anyone wants it:
http://www.oldworldaviaries.com/text/miscellaneous/blood_count.html
http://www.parrottalk.com/cbc.html
 
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Jennifer, I had a Polish pullet that got paralysis at 8 weeks old. I put her in the garage-she was just so cute. She had been vaccinated twice, 3 weeks apart. After a week I moved her into my bedroom. A few weeks go by and she is struggling to take a step. For a few more weeks, hubby and I practice putting her 10 feet away, and she has to walk back to us. She finally recovered enough to put her back out, and she's still fine as a 2 year old. The whole thing took about 6 weeks from beginning to end.

I wouldn't give up on your rooster yet. He might be able to fight it.
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Jennifer, I had a Polish pullet that got paralysis at 8 weeks old. I put her in the garage-she was just so cute. She had been vaccinated twice, 3 weeks apart. After a week I moved her into my bedroom. A few weeks go by and she is struggling to take a step. For a few more weeks, hubby and I practice putting her 10 feet away, and she has to walk back to us. She finally recovered enough to put her back out, and she's still fine as a 2 year old. The whole thing took about 6 weeks from beginning to end.

I wouldn't give up on your rooster yet. He might be able to fight it.
fl.gif

That would be a dream come true. He is just SO vigorous, which is the opposite of what I am used to with this disease.
 
My Hannah she just sat so prissy and innocently in this cage I had, sat there like that all day. When she lived in my bedroom, I used to take a nap with her on my bed.
 
Did you do anything special for her or give her any special supplements? I do not mean to follow false hope-- I know my rooster might still die, but since there is little else I can do for him I'll try nearly anything that won't harm him more.
 
Did you do anything special for her or give her any special supplements? I do not mean to follow false hope-- I know my rooster might still die, but since there is little else I can do for him I'll try nearly anything that won't harm him more.
No, nothing special. She may have gotten some yogurt. She had gotten the vaccine 3 weeks apart for 2 doses.
 
That would be a dream come true. He is just SO vigorous, which is the opposite of what I am used to with this disease.


Nambroth, thanks for posting all of the info from your vet visit. I keep praying that your rooster's immune system finds a way to fight off this terrible disease. I know how difficult it is and it brings tears to my eyes to read what you are going through. It brings me back to when I was going through it and I can feel my heart breaking again. I told myself that I wouldn't let this disease ruin my enthusiasm for raising chickens. But Marek's brings the toughest of us to our knees.

You have proven to be a great resource of information and moral support. Since this disease is ever changing and there still is a lot of unknowns, there is always hope that we can stumble upon a treatment or supportive care that might help the small few overcome it.
 
jennifer - I have no clue if it's helping, but since I had gotten it when my silkie had mareks, I've been using Tumeric extract in the water. You can't put too much in a small amount because it's nasty tasting. Haunted told me to use curcumin which is or is from tumeric. Also curcumin with bioperine is supposed to be good but I have a feeling you have to give lots for a long time. She said it cleans blood. Doc Peter Brown had told me to give 1100mg 3x a day which was 2 capsules 3x a day. That was his best suggestion when I talked to him. I might buy more of the tumeric when I'm out because it seems I've been lucky while I've been adding it, I'm scared to quit! Mine is liquid and I use about a dropper full/gallon.

I hope he will be ok. When not dealing directly with it, I tend to put it out of mind. out of sight out of mind but of course with mareks, that can never really happen.
 
I am posting this in case any of you would like to participate in this. I am going to see if my vet will come to the house to draw blood to send. Any way I can help them with research gives me hope they might come up with a better vaccine or even better....a cure!

For our best chance at isolating virus, we normally request to receive heparinized whole blood (at least 2ml/bird) shipped with cold packs overnight from at least 4-6 birds with lesions. The blood should not be in direct contact with the ice or cold packs because we don't want the blood to freeze. This is typically easiest by bleeding a number of cull birds and then sending us blood from appropriate birds after posting. It is helpful to know what the gross lesions were and MDV vaccination history. In the case of a backyard flock, you may not have cull birds in which case blood from the birds that look the most sick. I would be interested in samples from your flock or from the people you know with birds showing clinical signs of Marek's disease. I need about 2 days notice from when you plan to ship so I can have cell culture plates ready for trying to isolate the virus. Let me know if you need any materials for the collection.

Thanks!
___________________________________
John R. Dunn, DVM, MS, PhD
USDA-Agricultural Research Service
Avian Disease and Oncology Laboratory
 

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