I have two cats, one siamese spayed female who is 3 and a 2.5 year old siamese mix male who is neutered. They have been together since they were kittens and fixes as soon as their age allowed. They have been best buddies and NEVER fought. Yesterday I came home to pee and poop everywhere and my female hiding and howling behind my bed. After FINALLY getting her to come out I took her to the vet as I thought something was wrong. They could not find anything wrong with her and said she just seemed distressed. They wanted to know if anything had changed. Well nothing has, no new animals, no diff food, we haven't moved any furniture....nothing. These are two indoor cats that have NEVER had an accident outside of the box, or fought. They sleep together, groom each other, and eat together. Also, they have two litter boxes, two food bowls, LOTS of beds, two cat trees, two water bowls, and a ton of room. So I get Pearl (the female) home, let her out, and they are acting weird. I thought maybe she smelled funny to Dexter (the male) since she had been to the vet. Well they kept their distance and if one got to close the other would growl or hiss. Later we were getting ready for bed and a full blown fight broke out. So Dexter got locked in the guest room, and Pearl in our room for the night. They usually have the whole house together. This AM when we let them out a fight broke out immediately ending up with Pearls face bloody and a nail sheath stuck in her forehead. She also peed all over the house while running away from him. So they got a 3 hour timeout. I googled cat fights and read they can be weird if one smells funny so I rubbed them both in baby powder and put a drop of Vanilla Extract on their chins and noses. They are both out now but just slinking around staring at each other. I am sitting here watching them with a spray bottle and plan on spraying them if either of them starts. I am due with our first child in 4 weeks and if they don't straighten out soon hubby says one has to go. I have been crying all morning and need to get this sorted out. I just CAN'T re-home either, but also can't have them separated permanently, or running around like lunatics with a newborn in the house. ANY advice or info would be much appreciated, I am beside myself. Two other facts that may be important.... Dexter JUST had his yearly exam and shots a week ago..healthy as a horse. I have been cleaning up all the urine (Pearl dribbled while running away yesterday and today, and the poo I found yesterday) with Natures Miracle.