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I have had red cell work in a severely ill filly who was anemic due to a chronic bacterial infection in her gut.
I've had some calves and a puppy get severely anemic due to viruses. They puppy had parvovirus,which destroys red blood cells, and required multiple transfusions. The calves had multiple infections, I got them from a dairy and stools tested + for resistant e.coli, resistant salmonella, resistant staph and rotavirus. Probiotics, b-vitamins, electrolytes, Metamucil and subcutaneous fluids saved all of them. I also gave them red cell once they were nursing.