Big end up. If you have a turner, put them in large end up when you incubate also. Some say to let them rest for a few hours to overnight. I don't know if it makes much difference. A bigger concern would be whether you can store them at the right temp and humidity outside the incubator. I drop mine right in, but it won't hurt to let them rest large end up for up to 6 hours, in my opinion. But, since they are going to be large end up in the incubator for three weeks, I don't see the point.
UGCM