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Any health guarantee is better than none...However, dysplastic hips are often concealed until 2 yrs of age (which of course, is when this guarantee expires) OFA hip clearances can not be given until that age either. Mastiffs, being a large breed, grow much slower than the average sized breed, therefore hip dysplasia can show up even later. Health testing is so important in all breeds but particularly so for breeds such as the Mastiff.
There are several things to consider when purchasing a dog from a breeder.
What is the breeders goal ultimate goal? (To better the breed? If so, how is that particular pairing of animals improving the quality of confirmation and temperament in the breed?) If the breeder is producing puppies without properly testing the parents, (which should include, hips, hearts, eyes, among others) and without having a platform for comparative judging against breed or working standard, then you should assume that the purpose in breeding the animals is to profit...and when profiting is involved your aiding the millions of back yard breeders who contribute to the severe problem of pet overpopulation. Breeders who complete the proper health testing and pursue avenues of competition to properly evaluate their dog's worthiness of genetic contribution typically profit very little from the sale of their pups and are very selective when finding homes (very often these breeders will not ship puppies). If the breeder was producing a litter to have or sell "Christmas puppies" then you can bet they are making a great deal of "Christmas money" without ensuring the pet you purchase is sound in temperament and health.
Are the parents tested, and how far in the pedigree can proof of genetic and health testing be documented? Genetic abnormalities can be passed on through generations of poor breeding practice.
How often are their dogs being bred? (Breeding too often is bad for the mental and physical health of a dog. Breeding before 2 yrs. is harmful physically and prevents the breeder from properly evaluating the breeding stock as large breed dogs are not physically mature until 2 yrs.)
What is the guarantee? (Most health problems show up after 2 yrs. of age, when the contract expires...if this doesn't seem like a big deal to you, ask someone who has experienced the pain of losing a young animal to a genetic illness.
I hope this provides some insight. There is so much to consider when purchasing a puppy. There are millions of homeless pets, many of which are purebred and can be purchased from a reputable shelter or rescue at a fraction of a breeder's price and including full vetting and spay/neuter.
However, purchasing from an ethical breeder is smart, and contributing to educated breeders is a wise way to spend your money when shopping for a pet.