Unless they are already on the ground and acting slow I would wait until they have been on the ground a week. It will not hurt them to have it earlier. They don't have to be on the ground to get cocci as it travels on the air, your hands, and clothing including your shoes. The mixing directions on the bottle is fine for chicks, if you have the 25% it should be 2.0ml per quart, (liter).I know its been a little while but I was finally able to purchase it and receive it. How early can you give this to chicks? They are almost 4 weeks old. How much can I give them? They are not showing any signs of coccidia but I want to be proactive. Or should I wait until I out them outside?