The best of both worlds is a Combo gun, over/under, with the top barrel a rim or center fire and bottom a shot gun. I have one that is a .17/20ga. One for range and the other for movement. I don't think most people are very accurate with pistols, especially at long range and with an adrenalin rush going. Many pistol bullets start to tumble very quickly and loose accuracy fast, the .25 is one of the worst, it probably tumbles within a few feet after leaving the barrel.
I also swear that my .17HMR is THE BEST round that I have to tend to our coyotes, foxes, bobcats and dogs. I could use almost any caliber out there since I have many to choose from, but my .17 is always with me when I am out side working or driving around on my polaris ranger. I keep the .17 handy at night with a spot light and laser light attached to the scope. The .17 is quiet like a .22, costs about .30 cents a round ($15/50), shoots flat and gets to the target SO fast that when it hits it darn near explodes. I use hollow points and I can tell you, NONE of the predators I shot even came close to walking away, they just fell and died. I use a .300WSSM Browning Stalker as my deer and elk rifle, while I love the way it shoots and its range, I would never use that large of bullet arround where I live, it is an overkill for most predators, same could be said of my 30-06, .308, 7mm, 8mm, etc. I do however like my 22-250, but it is a lot louder than the .17. The only ammo I have for my .223 is FMJ and it would pass right though an animal and keep moving to the next county. I stopped using the .22 and .22 mag because it did not seem to be as effective on the larger predators, I had a lot of walkers with them.