If you are positive that it is not in the air cell, but it is chirping, what you have is a malposition. With such a large air cell, I'm guessing it is dry in there, and the chick has not been able to maneuver into position. I had one chick that I assisted. Her wing was glued over her beak. No way she could work with that! Are you positive this chick has passed day 21? Give it a while longer. It may still pip successfully. It may do some resting before it attempts to pip. so, if it goes silent for a bit, I wouldn't hit the panic button just yet. The time to hit the panic button is if the chick continues to chirp without pipping, and the chirping gets weaker. You could very carefully make a small air hole in the air-cell space. You're going to need to keep the humidity up high for this little one. I'd aim for 75%. Read the details about assisted hatch in Hatching 101. The fact that you're seeing blood vessels says it's not ready to hatch yet. I prefer not to assist until close to 24 hours after pip. (in this case, internal pip) That gives plenty of time for blood vessels to dry up. Your choice to either assist or not. You may assist and end up with an other healthy chick, or you may assist and the chick will die, or need to be culled. If you don't assist, the chick may hatch naturally and will be ok or not. If you don't assist... the chick may die in shell. It's basically a crap shoot! and you have to trust your judgement.