Yes, I'm talking about outcrossing to a different breed.
One they both mentioned is changes in egg shape. The dreaded Ping Pong Ball egg is a big sign of bad trouble. I've had some experience with that one. The eggs look absolutely round, sometimes the generation before will have a capsule looking egg, where the 'big' end is hard to discern from the 'small' end. In the case of Standard Cornish, where the chicks are really big in proportion to egg size, it is absolutely critical for the 'Big End' to actually be big so they can move their heads to pip. I'm in my F2 generation after outcrossing to survive a Ping Pong Egg crisis. I
I don't know if they would appreciate me talking too specifically about their flocks, but sometimes you will get a physical offtype from an established line (like a straight comb instead of a Pea or Rose). I've been told to not cull those individuals and 'carefully' put them back into the breeding program. Both believed that this comb variation represented an important linkage of genes that it was important for vitality to maintain it at some level.
If you are looking for an early indicator, Rate of Gain is a good place to start. I am going to be weighing chicks weekly until they are out of the brooder this year. A decrease in Rate of Gain is an indicator that vitality is being lost. One even suggested culling for Rate of Gain.
From my discussions in these flocks I got the impression that new blood was being added every 7-10 years depending on the breed and necessity.