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Not really, as long as you don't inhale it. A bit like water that way. All that gear is to prevent skin irritation (the scratchy means it's working!) and keep dust out of the lungs.
DE is plankton shells, (diatoms, genus Bacillariophyceae, which is a really fun word to say). It's almost entirely silica (which is not silicon).
Problem is, DE gets processed for several different uses. It's an anti-caking agent in food, a pool filtration medium, a spill-cleanup powder, and a pesticide, among other things. Each of these uses gets processed a little differently, and sometimes the DE gets other additives. The spill cleanup powder is made to absorb liquid, and it often has some other things in there to help. The pesticide can have all sorts of other things with it. the food additive has 98% or more of some other granular or powdery stuff (baking soda, salt, sugar, flour, etc.)
How do you know which one to get? READ THE LABEL!. If it says use it on poultry or on poultry bedding, or in poultry food, great. Use it. Only where the label says to. If not, don't.