If you raise chickens from chicks, you can handle them and they will be more comfortable around people. This may help if you get leghorn chicks. You can also clip the wing feathers to keep them from flying if you are going to keep the chickens in a chicken run with an open top. Many people clip the feathers of one wing of each chicken, because this makes them unbalanced when they try to fly.
I prefer the brown leghorns because they are more attractive than the whites, in my opinion. If you are in a cold weather area you can get rose comb light brown leghorns or rose comb dark brown leghorns. Brown leghorns lay almost as many large white eggs as the white leghorns, but the brown leghorns are better at avoiding predators when they are free ranging because of the color of their feathers.
If you want very friendly chickens, some of the larger brown layers are a better choice. For example, Buff Orpingtons are very friendly chickens that lay brown eggs. Some other calm brown layers include Delaware, Australorp, Jersey Giant, Plymouth Rock, Sussex, and Wyandotte. Dominique hens are also said to be friendly, while the roosters can be aggressive. Many people call these chickens "Dominikers." They look like Barred Plymouth Rocks, but the Dominiques have a rose comb.
I think if you get a mix of chicks they will be fine together in the coop and run. Most of the time you only have to be concerned about a rooster becoming aggressive, but not always. But you should be able to find a good rooster, if you should want one or if you want to hatch out some chicks. In that case you will also need a broody hen, and in a mixed flock you should have several broody hens.