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NUTRITIONAL AND METABOLIC CAUSES:
OTHER CAUSES:
Various chemicals and toxins are involved in kidney damage as;
NUTRITIONAL AND METABOLIC CAUSES:
- Excess dietary calcium with low available phosphorus results in precipitation of calcium-sodium-urate crystals. High levels of vitamin D3 can also increase calcium absorption from the gut which can favour formation and deposition of urate crystals.
- Excessive use of sodium bicarbonate when used to combat heat stress to improve egg shell quality in layers. This alkalinity of urine favours kidney stone formation.
- Prolonged vitamin A deficiency causes sloughing of tubular epithelium and subsequent blockade resulting in accumulation of urates in the kidney. However, incidence of gout due to vitamin A deficiency is least under field conditions.
- Gout due to sodium intoxication is seen in younger birds when the sodium levels exceed 0.4% in water and 0.8% in feed. This generally happens when fish meal is used in the diet (even with normal salt content), since fish meal is rich in salt content. Total content of sodium chloride in feed should not exceed 0.3%.
- Feed containing more than 30% of protein causes uric acid production which in turn creates an excretory load on kidneys. At the same time the presence of sulphates decreases calcium resorption causing excessive calcium secretion through urine. This condition favours gout.
- Water deprivation leads to concentration of uric acid and other minerals in the blood and later in the kidneys. Water deprivation especially in the summer is dangerous. This can happen during transportation of birds or due to blockage of nipples, inadequate number of waterers, extra height of water lines, overcrowding, water withholding for long durations during vaccination etc.
- Hard water with higher salt content is also a load on the kidneys.
OTHER CAUSES:
Various chemicals and toxins are involved in kidney damage as;
- MYCOTOXINS: Mycotoxins are the most common cause of kidney damage and among mycotoxins citrinin, ochratoxin and oosporin are important. The combination of ochratoxins with aflatoxin is found to be more dangerous. Because of kidney damage uric acid excretion is reduced resulting in accumulation of uric acid in the body.
- ANTIBIOTICS: Certain antibiotics like gentamycin, sulphonamides and nitrofurosones are known to cause renal damage especially in young chicks. The drugs which get excreted through the kidneys have their own imbalancing effect on pH and renal metabolism.
- DISINFECTANTS: Disinfectants like phenol and cresol if used erroneously cause residual toxicity.
- CHEMICALS: Chemicals like copper sulphate used in water results in water refusal, dehydration and gout.