@kerbotx I am unable to quote you for some reason, but here is your reply "" I don't have a readily linked source, but I believe it's now been proven that Amprolium
mimics thiamine, it does not actually block it - so no risk of deficiency."
Here's some information about how Amprolium works:
It is
thiamine antagonist and due to its close structural similarity it blocks the thiamine receptors. This blockage of receptors prevents coccidia from utilizing thiamine and as a result thiamine is unavailable to coccidian (Competitive inhibition of thiamine uptake). This vitamin (thiamine pyrophosphate) is a cofactor of several decarboxylase enzymes which play role in cofactor synthesis. It is only agent which can be used in laying birds both for prevention and treatment of outbreaks.
At higher doses, thiamine deficiency can occur in host but it can be prevented by addition of thiamine."
Source:
http://www.poultrymed.com/Amprolium
There would risk of deficiency when Amprolium is given long term (at outbreak dosage levels). Treatment period for poultry is 5-7 days, so unlikely a deficiency would occur.
But, most medicated feeds are at preventative levels, so...B1 (Thiamine) deficiency would not be that big of a concern, plus feed does contain B1 in a balanced proportion.
Plumb's Vet Drug Manual under Amprolium states : "excessive thiamine in the diet can reduce or reverse the anticoccidial activity of the drug"
Nothing defines "excessive", so one would just have to assume that the
balanced poultry feed would not contain excessive amounts of Thiamine that would contradict the medication.