I have had some eggs shipped i with thoes. Both inside the box and outside. Don't know if they help on the outside, but will give you my opinion on the inside. They will make a lot of difference. I work for a biotech firm. We freeze a lot of products in a -20c blast freezer. We need to ship product and it has to fit in specific boxes and arrive frozen.So we tested many different methods of freezing and shipping our product. Our product would be placed in freezer at 100 degrees. We placed data loggers in pacakges with the product. We would freeze liquid blood plasma in packages from 500 ml to 10000 ml. so about 1 pint to about 4 gallons. It was surpizing that in open air these varying sizes would freeze at about the same rate, If we placed them in boxes that were open , it would take about 24 more hrs to freeze to the same temp as bags laying on the shelf. This is at a freezer temp of - 4 f with the wind = 20 mph. If we closed the boxes , it took over 72 to 96 hrs to freeze. So a simple cardboard box was a hugh insulator. And this was with a constant wind over the product. to help disapate heat. Thses heat packs provide heat up to 72 hrs and get to anout 120 degrees. It may be detrimentale to place them to close to eggs, in a box during shipping. They may heat the eggs to the point of starting the embryo developement. Most mail isnot exposed to that extreme of temp. Bubble wrap and other packing material adds more insulaton. Most eggs, if packed and shipped , can get there with out danger of freezing. How ever, they may be frozen before shipping if they come from a cold area of the country. I have never recieved frozen eggs, even in the coldest months in the midwest.