Sounds like she needs a visit to the doctor or ER asap. Even if it's just a reaction to the medication, there could be more stuff going on. I realize she's 104, but sudden altered mental status like this is cause for concern. If she's not showing any sign of improvement, I would call 911 and have them take her to the ER. I'm not a doctor, but as an EMT we see a lot of elderly women with UTI's showing sudden altered mental status. It's something easily taken care of, but often requires hospitalization and could get worse without treatment.