OK. I found it. Mind you, it may not have anything to do with your problem...just another brainstorming idea to look at. This comes out of "Hatching and rearing your birds" It comes out of the UK. Looks like most the book was written by Terry Beebe (Practical Poultry).
Anyway, there is a Q & A section in the back of the book. One of the questions was from a man who had 30 chicks in his brooder. He said "...but I have lost 19 chicks of various breeds, mostly Silkies and Faverolles. There appears to be nothing wrong with them as far as I can see but obviously there is. They do not have mite or dirty vents and seemed perfectly healthy one day but dead by the next morning. The chicks are from 2 - 5 weeks old."
The answer goes into some obvious reasons.....infection inside the brooder, overcrowding, and coccidiosis, but then he says, "You also mention two breeds, one of which is the Silkie. This could be another possible cause of your problems as most Silkie chickens are vaccinated against Meraks, a disease from which they are prone to suffer. If they are not vaccinated they will in most cases die and may also infect the other chicks in the brooder. You really have to be careful that you do not mix breeds that are normally vaccinated with breeds that are non-vaccinated as this can lead to some very serious infections and in most cases many fatalities. "
I had this happen to me....a man gave me some mixed breed chicks...mostly silkie mixes and some had Faverolle in them, too. They all seemed fine and I would walk in there and take a picture one minute and then an hour later, that chick would be dead. I lost all but one and my Isbar. They were all between 2 - 4 weeks old when they died.
Maybe this is the case with the Isbars? I don't know....just a thought. May have absolutely nothing to do with Isbars or what happened to your chicks. But, if one breeder is vaccinating and the other is not, and some of that is passed thru to the chicks and then you breed them, might be something to think about? Isbars are fairly new here, so maybe they are like the Silkies and Faverolles?
Anyway, I hope you find out what happened and let us know.