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It's not necessarily only an issue with them per se. Once they have recovered from a single treatment, it is best to leave it as is and let their natural systems take over.
Each treatment with the same drug will just increase the percentage of "bad resistant" bugs. Eventually the percentage of "bad resistant" ones get too large, you will have a problem you can't fix anymore. Small bits of bad can be combated by the natural immunity of living things AND the presence of healthy bacteria taking up resources that the bad ones need to survive.
The more concerning part though, is bacteria can exchange their immunities to drugs with each other by just contact. They carry immunity genes on plasmids, which are little bits of DNA which float around inside them. This is something good to be aware of because bacteria on a chicken who is resistant to a med you use on it, can "gift" that resistance plasmid to a bacteria on your skin, which can "gift" that to other bacteria and so on. (Horizontal gene transfer) This can make certain antibiotics not even work on you or your other pets, even if you've never taken the drug or administered it to another animal.
I avoid antibiotics unless absolutely necessary, when when in use, use a full course only once.
