I had mites get going with my birds this year. I handle them semi regularly. If I find one bird with one mite or louse, I treat them all. For a reason, I was not handling them as frequently, and when I did I had an actual start to an infestation. It was interesting to note that in a given pen, that a single bird would have more than the rest. I did mark those birds. I did not cull them but I will know when I set my pens up. If all else is equal, I may not use them.
There is value in not breeding the most vulnerable birds. These birds can be considered less fit. It is difficult to know why they succumbed and others did not.
Often, it's worth having something bad happen, the knowledge you can gain is invaluable. I only keep vulnerable birds if they've made pets of themselves, generally, but as you say, it is hard to know why they were vulnerable in the first place.
I experimented with a rooster I had years ago, a severely ill bird, and found that for all intents and purposes, as far as I could test it, the fault of his weakness was not his; his offspring were vigorous and vibrantly healthy --- I still have his lines in my flock, some of the oldest and all tough, healthy birds, never ill --- but one of his first offspring, a son, had the dubious distinction of being infested by Old World Screw-Worm and some other currently unidentified type of flesh-eating maggot, and I wonder, is that just a coincidence?
(Just found out recently what one of those species of maggot was, the OWSW; the poor rooster had the first case known in Australia, which was previously considered free of OWSW. What's the odds?!)
Oh, and he was also the only chicken I ever had that got Blackhead. Which he did, twice. While he was unable to walk due to the maggots (or was it something else?)... His immune system had no problems dealing with the Blackhead within a 24 hour period, both times, but clearly he was not on an upwards trend there...
You know, the more I think about this, the more I think it's rather incredibly unlikely to be a coincidence that he got hit with a perfect storm when none of the others (bar his father) ever did...
The father appeared to have complete immune system collapse when he was given to me as a cockerel, I suspect due to some extremely severe toxicity, probably with attendant DNA damage since that's usually how it goes, but he recovered for a year there and I experimented and let him breed. Then his son cops a case of two species of flesh-eating maggots coexisting peacefully in him, that not a single other one of all my hundreds of chooks reared in that place, before, or since, ever got... It's not like he was the only chook or other animal on that place to ever sport a potential entry wound for those maggots, either. In fact I wonder if they even need one; theoretically they do, but I couldn't find it. His tail looked normal except for some little maggots in a small wound, which I left thinking they were just necrotic-flesh-eaters such as are rather common in some livestock (not mine, lol, that was a first for me)... But they rapidly ate the tail hollow, and moved into his abdomen before I found out that they were not the sort that cleans up rotting flesh, but rather consumes live flesh. Too late, and it all happened in a few days).
Another random find about susceptible/vulnerable individuals... While not being able to look after my birds like I usually do, I found one line is extremely susceptible to scaly leg mite as well as having some kind of hormone disorder that only kicks in after 2 years old.
Almost all my other lines just don't get scaly leg mite, even with complete exposure; some get it to a very mild degree. None of the other lines have hormone problems of any visible sort, to the best of my knowledge they're free of them. Another coincidence? Probably not...
These were hens I was going to cull anyway, from new blood in the flock that I tried years ago, but wasn't impressed with, but when I traveled I kept them for a bit longer than usual, to help supply eggs since I'd whittled down the flock a lot. Since I was traveling them and agisting them the quality of their diet dropped dramatically, and it's become most obvious that without a decent diet to help them, they show their serious shortcomings. They can't maintain a pretense of being robust on a lower value diet, but they sure can pass on a better one. Bad line.
The rest of my lines remain fine despite the frequently poor conditions they've lived through while I moved them, which has been good to find out even if it's been an unfortunate experience for all involved, but this particular line just nosedived; offspring they had are being overrun by scaly leg mite as chicks. Never seen anything like it.
Never would have found that out if I were able to look after them as I usually do. Possibly wouldn't have been a problem because I was going to cull them anyway, and never intended to breed them, but, education is invaluable, so I'm glad I learned. Now I need to review my journals and what it was that made me decide to cull them in the first place, just to look for possible clues; they had multiple points of failure, but I'm wondering if there is a 'type' I need to avoid here, because those hens are all as alike as peas in a pod and all have the same problems, as do their very similar offspring; hardly likely to be coincidental. Too many problems seem to have multiple cues, like one line of those Leukosis carriers I had, only their blue/purple skinned, white feathered, silkie-type offspring ever suffered from it. All other offspring of different phenotypes never had a problem. Now I'm wondering if there is a phenotype more susceptible to MD.
Best wishes.
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