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Old worn out RN here. The simple answer is, most do. Especially if it is not an old time-worn drug.
I tried Chantix to quit smoking. I have never been depressed, much less suicidal, in my life, until a few weeks into that stuff. I found myself seriously considering suicide. I was also having some hallucinations which seemed quite believable. Fortunately, there was a part of me that was watching this stuff, and knew it was all a drug reaction.
Prednisone does a whole bunch of things. I really hope it is a limited prescription, meaning, he will be off it in a few weeks. If not, if this is to be a permanent drug, best do some extensive reading.
The Dr's wanted it to be a limited prescription for Pred, but he does not do well with pain (flair ups) so he takes it when he "needs" it. I think that it is basically the problem. It's been YEARS that he's taking the pred, don't you think that is a lot? I do. I'm seeing a big difference in attitude and personality. That is what I'm not liking at all. If you need to take them for an acquired amount of time, so be it. But....I think he's afraid of the pain, ok I have not had that kind of pain, and I understand it's different for different people, but...Long term effects on that kind of stuff....well I don't trust any Dr to tell you "No you shouldn't take that for too long" BS they still prescribe it. OR... you can get that on line...
m