I guess I qualify as rabbit people - as I have 6 indoor bunnies, and frequently stop at neighbor bunny pens - to provide clean hay, water, pellets, comfort, clip their nails, clean their scent glands - etc. Rabbits have got to be the most misunderstood creature in the world -- I mean -- they are not dogs and cats -- who have a fairly similar digestive tract as humans, and yet pet stores sell them like kid toys to plant in their yard -- with minimum care and attention to the details that rabbits need to be healthy and happy. Chickens on the other hand -- are easier than cats and dogs - given protection from weather - but can never be litter box trained. Anyway - It does sound like your bunny is having inner ear problems -- easy to acquire without fresh hay daily - especially given the amount of rain lately - and the result of moldy hay. But then try to find a vet who knows the basic internal anatomy of a rabbit... Without the presence of mites -- there is always the possibility of a bacteria that presents itself as 'snuffles' - (wet nose - eyes ) that can more or less migrate around the body -- even rest in the brain -- causing neurological damage. The best online bunny site for searching out problems - -is Rabbit Ref. Her behaviour change from friendly to defensive - is most likely linked to 'cage agression' which is almost always present in unspayed females. As they develop from sweet little girls to young adults -- their hormones kick in - with or without a male stimulus -- and their pen becomes a place to defend their potential young. Not unlike a dog in a car. It doesn't get any better -- even if you have a daily handling relationship -- they will behave erratically -- until spayed. Rabbits are about the most difficult creature for a kid to take care of properly -- without adult help. And it's always the bunny that suffers -- despite the nips they can so easily give. You could ask around for 4H folks -- who would know a bit more - and maybe help you out. I let mine run round the kitchen -- they are easily litter box trained -- and love to be held - and are quite delightful once a relationship is developed. Good luck. And like chickens -- clean water, food, and bedding goes a long way...