Pullet flinging mucus WHILE getting Tylan 50 injections

Source: http://www.chelonia.org/articles/medical_misinformation.htm

A second drug that is widely utilized in chelonian medicine is Baytril. Again, this is a tradename for a drug which in this case is enrofloxacin. Enrofloxacin is a member of the antibacterial group, the fluoroquinolones.
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Again, dosages for this drug are widely circulated on the internet. Unfortunately, the utilization of drugs such as this is often inappropriate and even harmful. Pathogenic organisms such as hexamita, viral organisms, fungal organisms, parasites, and protozoal organisms are all unaffected (or in some cases even encouraged by the destruction of their “competition”) by the usage of antibiotics yet are often the cause of the underlying problem in the animal. Baytril can also have severe side effects.

For example, long term usage of antibiotics can destroy the normal gastrointestinal flora of chelonia. This in turn can lead to the overgrowth of some rather nasty resistant bacterial organisms as well as fungal organisms. Obtaining a culture and sensitivity is necessary to pinpoint exactly what organism is causing the problem as well as determining the most effective treatment option. Bacterial resistance to numerous antibiotics is becoming the norm rather than the exception to the rule. Having your vet run an inexpensive culture and sensitivity not only saves time but also improves the odds of proper and effective treatment.
A second side effect which I have noted personally in Geomyda spengleri, Geochelone denticulata, and Heosemys spinosa and which has been reported anecdotally in several other species is that baytril can cause a severe “allergic type” reaction in a number of animals. This reaction consists of violent vomiting, diarrhea, and an almost comatose state with all four limbs and the head fully extended within a few minutes of the injection. The comatose state can last varying periods of time stretching into a few days.
Batyril was initially developed in dogs and the following information is from the label. “Enrofloxacin may lower the seizure threshhold (meaning that it can facilitate seizures). This is not a problem for normal animals but fluoroquinolones are best not used in animals with known seizure disorders.” Also note: “At approximately ten times the recommended dose vomiting and diarrhea may be seen with this medication. At normal doses, this should not be seen. Dogs with Pseudomonas ear infections require very high doses of enrofloxacin and nausea may indeed become a problem.”
Next, baytril is an EXTREMELY painful drug if given in the “wrong” place. Intramuscular injections into the musculature of the front legs is an outdated treatment modality and leads to the classic ‘Baytril pain dance” which is easily avoided with appropriate administration of the drug.
Baytril has also been found to cause damage to the joint cartilage in immature (less than 8 month old) dogs. I have seen this in immature birds as well and have no reason to believe it doesn’t cause similar problems in developing chelonians. Permanent damage to the retinas in cats and subsequent blindness is another side effect which wasn’t discovered until the past few years.
Lastly, most people are unaware that Baytril is actually designed to be given intramuscularly for the initial treatment and then orally for subsequent treatments. It is not designed to be given repeatedly into the muscle yet this is the primary approach utilized in most instances as well as that “prescribed” by internet “experts”.
To summarize, I would strongly encourage everyone to make full use of their veterinarian. We are not only trained medical professionals but we have years of experience, continuing education, and diagnostic skills/equipment that can be brought to bear on your animal’s medical problems. Relying on “cookbook drug recipes” on the internet is not only dangerous but also irresponsible. The animals in our care deserve the best we can provide.
BAYTRIL IS NOT PAINFUL GIVEN CORRECTLY AND I AGREE THAT DOSING IS SUBJECT TO DISCUSSION THAT IS WHY IT IS VERY VERY IMPORTANT TO CONSULT A VET OR A UNIVERSITY THAT HAS AN AVIAN DEPT OR THE NPIP TO HAVE YOUR BIRDS PROPERLY DIAGNOSED....MINE ARE ALSO PETS...I HAVE AN OLD SCHOOL VET AND TRUST HIM FULLY AFTER 16YRS ,THE UGA PROFESSOR IS THE ONE THAT SAID YOU CAN NEVER EAT THE BIRDS OR THEIR EGGS....WHEN BAYTRIL FIRST CAME OUT THE POULTRY INDUSTRY THOUGHT IT WAS A MIRACLE DRUG UNTIL THE FDA PULLED IT FROM BEING USED IN POULTRY AS IT CAN INTERFERE WITH FOOD BORNE ILLNESS TREATMENTS....I AM NOT A VET THIS IS MY OWN PERSONAL SITUATION.
 
That hadn't occurred to me, but it does make sense. Maybe they had been drinking water and I picked them up right afterwards. And the liquid I saw was simply the water they had just drank. You mean, it could be that simple?
 
I took 2 of my birds to UGA to have a Necropsy done and both of them were given Tylan IM and at the sites (breast muscle) the muscle was dying, not trying to scare you but the Professor said tylan is a powerful antibiotic and given IM can cause muscle atrophy which we all know that chickens use their breast muscles to breath that is why it is very important to give SUB-Q just under the skin it is also hard to do with all the little veins...So I immediately stopped the tylan and started them on the keflex as I said previously.Poultry Pedia has a Medication Chart it also says IM but I learned the hard way....any shot you give you should give in the Nap of their neck like you would a dog, pull the nap up to make a little tent stick the needle in the tent just under the skin it is hard to do but it can be done by yourself better if you have help to fight back the feathers and hold the bird still that is why I recommended insulin needles they are very small and almost painless. But please have your birds tested call NPIP
Did you know that injectable enrofloxacin (Baytril) can cause injection site abscesses even when give SC?
 
Baytril 100... YOU CAN NEVER EAT THE BIRDS OR THE EGGS FROM BIRDS THAT ARE TREATED WITH BAYTRIL.

So, the purpose of this would be to get the next generation hatched and growing before culling the rest of the flock, right?
 
BAYTRIL IS NOT PAINFUL GIVEN CORRECTLY AND I AGREE THAT DOSING IS SUBJECT TO DISCUSSION THAT IS WHY IT IS VERY VERY IMPORTANT TO CONSULT A VET OR A UNIVERSITY THAT HAS AN AVIAN DEPT OR THE NPIP TO HAVE YOUR BIRDS PROPERLY DIAGNOSED....MINE ARE ALSO PETS...I HAVE AN OLD SCHOOL VET AND TRUST HIM FULLY AFTER 16YRS ,THE UGA PROFESSOR IS THE ONE THAT SAID YOU CAN NEVER EAT THE BIRDS OR THEIR EGGS....WHEN BAYTRIL FIRST CAME OUT THE POULTRY INDUSTRY THOUGHT IT WAS A MIRACLE DRUG UNTIL THE FDA PULLED IT FROM BEING USED IN POULTRY AS IT CAN INTERFERE WITH FOOD BORNE ILLNESS TREATMENTS....I AM NOT A VET THIS IS MY OWN PERSONAL SITUATION.

Could someone please explain to me why you can never eat the meat or eggs from a bird treated with Baytril? We have already seen at least one study that showed a withdrawal period of as little as 4 days for eggs and 5 days for meat. It seems unlikely that an antibiotic would remain in an animal's tissues for the remainder of its life after being treated for 5 days, so I'd love if someone could provide an explanation based on science rather than 'so and so said'. Thanks!
 
Could someone please explain to me why you can never eat the meat or eggs from a bird treated with Baytril? We have already seen at least one study that showed a withdrawal period of as little as 4 days for eggs and 5 days for meat. It seems unlikely that an antibiotic would remain in an animal's tissues for the remainder of its life after being treated for 5 days, so I'd love if someone could provide an explanation based on science rather than 'so and so said'. Thanks!
Source:http://www.ucsusa.org/action/progress/8-2005-baytril.html

FDA bans the use of the animal-antibiotic Baytril in poultry

In August 2005—after several years of pressure from the Union of Concerned Scientists and the coalition group Keep Antibiotics Working (KAW)—the Food and Drug Administration (FDA) made history by banning the use of the animal-antibiotic Baytril in poultry due to worries about the increase in antibiotic-resistant infections in people.
This action marks the first time the FDA has withdrawn an agricultural antibiotic from the market because of concerns about antibiotic resistance affecting human health. Baytril is a fluoroquinolone antibiotic, much like the commonly used human antibiotic Cipro. Cipro is one of the most effective treatments against serious cases of food poisoning and other bacterial infections. Since Baytril's approval for use in poultry in 1996, strains of foodborne illness resistant to Cipro and similar drugs have increased dramatically. The FDA's decision to remove Baytril from use in poultry will take effect September 12, 2005.
 
Source: http://evolution.berkeley.edu/evolibrary/news/050915_baytril

"Just say no to drugs" was the message sent to chicken farmers in July of 2005 when the FDA banned the use of the antibiotic Baytril in poultry production. Citing concerns for human health, the FDA will no longer allow poultry producers to give their chickens, turkeys, and ducks Baytril-laced water to treat and prevent respiratory infections in the birds. That move reinforced the actions of McDonald's, Wendy's, and other fast food giants that have, in recent years, refused to buy chicken treated with Baytril and other selected drugs. Even the pork industry is getting in on the act. In August, Smithfield Foods Inc., the company likely to have supplied that glazed ham for your Sunday supper, announced that it would stop treating its pigs with selected antibiotics for growth-promotion purposes.
Where's the evolution?
But how does using an antibiotic on chickens and pigs affect human health, and what does this all have to do with evolution? At issue is the evolution of antibiotic resistant bacteria.
When a farmer treats a chicken flock with the antibiotic Baytril, it kills most of the bacteria responsible for the respiratory infection — but it also kills many of the campylobacter bacteria that naturally live in the chickens' guts. Ever take an antibiotic for strep throat and wind up with an upset stomach? You've done the same thing — killed most of your naturally-occurring gut bacteria!
Here's the problem: not all of the campylobacter are killed, and the few that survive probably carry a mutation that makes them resistant to Baytril. These resistant campylobacter then pass that mutation on to their offspring as they multiply. Hence, natural selection causes the evolution of Baytril-resistant campylobacter bacteria. If campylobacter get into your body (perhaps through contaminated chicken meat), you may wind up with food-poisoning. With normal campylobacter, you could just take the antibiotic Cipro to clear up the infection — but since Baytril and Cipro are similar antibiotics, Baytril-resistant bacteria are also likely to be Cipro-resistant...and, voila, you end up with a terrible case of food-poisoning and no useful drug to treat it.
The potential ramifications become even more frightening when you consider the fact that bacteria have the unusual ability to pass genes back and forth between species in a process called horizontal transfer. Cipro is one of the few antibiotics used to fight the anthrax bacterium. If a campylobacter passed its Cipro-resistance gene on to an anthrax bacterium, we could end up facing a frightening "super-bug."
The evolution of antibiotic resistant bacteria is a serious concern — and it is not just limited to Baytril. Many human antibiotics have sister-drugs that are freely used on livestock in copious amounts. The presence of these antibiotics sets the stage for the evolution of resistant bacteria in any environment: in the animals themselves or in the soil and water contaminated by the antibiotic.

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News update, August 2009
In 2005, the FDA banned the preventative use of the antibiotic Baytril in poultry production. This move was aimed at slowing the evolution of drug resistant bacteria that threaten human health. Exposure to Baytril is likely to select for strains of bacteria resistant to the critical human antibiotic Cipro. However, since this first step, the FDA has taken no further action curbing the use of other antibiotics in livestock — though tens of millions of pounds of these drugs are used on U.S. livestock and tens of thousands of people die as the result of antibiotic resistant infections each year.
Now, Congress and the Administration may be picking up where the FDA left off. In March of this year, a bill to limit the use of antibiotics in livestock feed was introduced in the House of Representatives. And in July, the Principal Deputy Commissioner of Food and Drugs came out in favor of the new legislation — which would phase out the preventative use of medically important antibiotics in livestock and require that new animal antibiotics be evaluated against the same criteria. Under the new legislation, the drugs could still be used to treat sick animals. If the bill goes into effect, it would recognize the evolutionary consequences of our actions and, in so doing, help modern medicine fight the battle against drug resistant pathogens.

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Read more about it
Primary literature:
  • Gaunt, P.N., and Piddock, L.J.V. (1996). Ciprofloxacin resistant Campylobacter spp. in humans: An epidemiological and laboratory study. Journal of Antimicrobial Chemotherapy 37:747-757.


News articles:


Understanding Evolution resources:


Discussion and extension questions

  1. What role did evolution play in the decision to ban the use of Baytril in poultry?
  2. Why do antibiotic resistant bacteria in chickens threaten human health?
  3. Compare bacterial evolution to human evolution. How are they similar, and how are they different?
  4. Compare and contrast the role of natural selection in producing antibiotic resistant bacteria and in producing a dangerous strain of the avian flu (see Evolution and the avian flu).
  5. What strategies can help prevent the evolution of antibiotic resistant bacteria?


Related lessons and teaching resources

  • Teach about natural selection. In this classroom activity for grades 9-12, students experience one mechanism for evolution through a simulation that models the principles of natural selection and helps answer the question: How might biological change have occurred and been reinforced over time?
  • Teach about another application of evolutionary theory in medicine. In this classroom activity for grades 9-12, students learn why evolution is at the heart of a world health threat by investigating the increasing problem of antibiotic resistance in menacing diseases such as tuberculosis.


References

  • Citing human threat, U.S. bans a poultry drug. (2005, July 29). The New York Times, p. A17.
  • FDA bans some antibiotics in poultry. Talk of the nation/Science Friday. Ira Flatow (anchor). National Public Radio. (2005, August 19).
  • Gardiner, H. (2009, July 14). Administration seeks to restrict antibiotics in livestock. The New York Times, p A18.
  • Mellon, M. (2009, July 13). Testimony Before the House Committee on Rules On The Preservation of Antibiotics for Medical Treatment Act H.R. 1549. Retrieved July 29, 2009 from Union of Concerned Scientists.
  • Pork Barrel. (2005, August 11). Nature 436:775.
  • Sharfstein, J. M. (2009, July 13). Testimony of Joshua M. Sharfstein M.D., Principal Deputy Commissioner of Food and Drugs, Food and Drug Administration, Hearing on H.R. 1549, "Preservation of Antibiotics for Medical Treatment Act of 2009." Retrieved July 29, 2009 from U.S. House of Representatives Committee on Rules.
  • Union of Concerned Scientists. (2004, April 7). Hogging it!: estimates of antimicrobial abuse in livestock (2001). Retrieved July 29, 2009 from Union of Concerned Scientists.
 
Source:http://www.ucsusa.org/action/progress/8-2005-baytril.html

FDA bans the use of the animal-antibiotic Baytril in poultry

In August 2005—after several years of pressure from the Union of Concerned Scientists and the coalition group Keep Antibiotics Working (KAW)—the Food and Drug Administration (FDA) made history by banning the use of the animal-antibiotic Baytril in poultry due to worries about the increase in antibiotic-resistant infections in people.
This action marks the first time the FDA has withdrawn an agricultural antibiotic from the market because of concerns about antibiotic resistance affecting human health. Baytril is a fluoroquinolone antibiotic, much like the commonly used human antibiotic Cipro. Cipro is one of the most effective treatments against serious cases of food poisoning and other bacterial infections. Since Baytril's approval for use in poultry in 1996, strains of foodborne illness resistant to Cipro and similar drugs have increased dramatically. The FDA's decision to remove Baytril from use in poultry will take effect September 12, 2005.

Thank you, but that still doesn't answer my question.
 

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